2,5-Dimethoxy-4-chloroamphetamine (DOC) is a psychedelic drug of the phenethylamine and amphetamine chemical classes. It was presumably first synthesized by Alexander Shulgin, and was described in his book PiHKAL (Phenethylamines i Have Known And Loved).
Unlike simple amphetamines, DOC is considered a chemical that influences cognitive and perception processes of the brain. The strongest supposed effects include open and closed eye visuals, increased awareness of sound and movement, and euphoria.
Although rare on the black market, it has been available in bulk and shipped worldwide by select elite “Grey Market” Research Chemical suppliers for several years. Sales of DOC on blotting paper and in capsules was reported in late 2005 and again in late 2007. According to the DEA’s Microgram from December 2007, the Concord Police Department in Contra Costa County, California, in the US, seized “a small piece of crudely lined white blotter paper without any design, suspected LSD ‘blotter acid'”. They added “Unusually, the paper appeared to be hand-lined using two pens, in squares measuring approximately 6 x 6 millimeters. The paper displayed fluorescence when irradiated at 365 nanometers; however, color testing for LSD with para-dimethylaminobenzaldehyde (Ehrlich’s reagent) was negative. Analysis of a methanol extract by GC/MS indicated not LSD but rather DOC (not quantitated but a high loading based on the TIC)”. DOC is sometimes misrepresented as LSD by unscrupulous dealers. This is particularly dangerous, as DOC is not known to have the safety profile of LSD. It can be particularly unsafe, in comparison to LSD, for those suffering from hypertension, as amphetamine compounds are known to cause sharp increases in systolic blood pressure.
DOC is not scheduled or controlled at the federal level in the United States,[15] but the Department of Justice considers it to be an analogue of DOB and, as such, possession or sale could be prosecuted under the Federal Analogue Act. In the United States, the analogues DMA, DOB, and DOM are Schedule I controlled substances.